Malaria is a life-threatening disease spread to humans caused by single-celled microorganisms of the Plasmodium group. The disease is widespread in the tropical and subtropical regions that exist in a broad band around the equator. In this paper we report the molecular docking studies of 9 thiazolidinedione derivatives having antimalarial activity. The derived compounds were analyzed for drug likeness based on the Lipinski’s rule of five and protein-ligand docking studies by Autodockvina with PyRx and visualized by Biovia Discovery studio 2021 Client. Docking studies have shown that the thiazolidinedione derivatives interacts and bind efficiently with protein (1P44 (enoyl-acyl carrier protein reductase (InhA)) enzyme which resulted in antimalarial activity